Journal: Frontiers in Cell and Developmental Biology
Article Title: (Multi-) omics studies of ILC2s in inflammation and metabolic diseases
doi: 10.3389/fcell.2024.1473616
Figure Lengend Snippet: ILC2 metabolism in healthy and diseased state (A) In healthy homeostatic state, ILC2s use glycolysis and FAO to fuel OXPHOS for the production of IL-5, IL-13 cytokines to maintain their survival. (B) Upon helminth infection in the lung, IL-33 is released which in turn activates ILC2s, leading to FAO and Arg1 activity for IL-13 production in order to enhance the anti-inflammatory and tissue-repair functions of ILC2s. (C) In metabolic disorders, impaired metabolism due to high glucose and free fatty acids (FFA), ILC2 metabolism is disrupted, partly leading to increased glycolysis to manage the excess of glucose Abbreviations: Arginase-1 (Arg1), Fatty acid oxidation (FAO), Free fatty acids (FFA), Innate lymphoid cells type 2 (ILC2s), Interleukin (IL), oxidative phosphorylation (OXPHOS). Made with biorender.com . The “?” indicates that there is a yet unknown mechanism.
Article Snippet: Epigenomics , DNA methylation and histone modification patterns in ILC2s during cardiovascular stress , Epigenetic regulation of ILC differentiation and function affecting cardiovascular disease progression and response to therapy , .
Techniques: Infection, Activity Assay, Phospho-proteomics